THE USE OF CD40:CD154 BINDING INTERRUPTER TO PREVENT COUNTERADAPTIVE IMMUNE RESPONSES, PARTICULARLYNT COUNTERADAPTIVE IMMUNE RESPONSES, PARTICULARLY GRAFT REJECTION GRAFT REJECTION

摘要

The compositions and the methods are used for extending the survival of the graft tissue in a host recepient in order to avoid any acute rejection of the graft and reduce the immunologocal consequences of the failure of the graft. The rejection of a tissue graft can be inhibited by using CD40:CD154 interupter of binding be it individual or in combination with another immunomodulator or immunosuppressor. The synergic combination includes CD40:CD154 interrupter of binding and CD28 interrupter of feeding the signal. An example for a CD40:CD154 connection interrupter is an anti-CD154 monoclonal antibody as an antibody having antigen-specific characteristics of binding of 5c8 monoclonal antibody. An example for CD28 interrupter of signalling is CTLA4-lg merged protein. 51 claims