Purified polynucleotide, dna, vector, host cell, hybridoma cell line, monoclonal antibody, processes to produce exodus, to increase resistance to infection by human immunodeficiency virus (hiv), for treatment of human immunodeficiency virus (hiv) infection , for the protection of bone marrow progenitor cells against cytotoxic effects and for the treatment of myeloproliferative diseases, and the use of an exodus protein product.

摘要

"PURIFIED POLYNUCLEOTYDE, DNA, VECTOR, HOSTING CELL, HIBRIDOMA CELL LINE, MONOCLONAL ANTIBODY, PROCESSES TO PRODUCE EXODUS, TO INCREASE THE RESISTANCE TO INFECTION BY HUMAN IMMUNE IMPROVEMENT VIRUS (HUMAN HUMAN INFECTION (HUMAN HUMAN INFECTION) ), FOR PROTECTION OF BONE MARROW PROGENITOR CELLS AGAINST CITOTOPXIC EFFECTS AND FOR TREATMENT OF MYELOPROLIFERATIVE DISEASES, AND USE OF THE EXODUS PROTEIN PRODUCT ". The present invention provides purified and isolated polynucleotide sequences, which encode a human macrophage-derived C-C chemokine designated as Exodus. Isolated and purified chemokine protein, fragments and polypeptides analogous thereto, antibodies to it, and materials and processes for recombinant production thereof are also provided. These products are useful in therapeutic, diagnostic and medical imaging applications.