The compound, pharmaceutical composition, use of the compound, and processes to produce a compound for preventing or treating an inflammatory disease, rheumatism,CrÈnica rheumatoid arthritis and autoi

摘要

"Compound, pharmaceutical composition, use of the compound, and processes to produce a compound for preventing or treating an inflammatory disease, rheumatism,Cru00c8nica rheumatoid arthritis and autoimmune diseases to prevent rejection after organ transplantation, and to inhibit the ressoru00e7u00e3o bone, osteoporosis and the production of cytokines in a mamu00ecfero ".Describes a compound of formula (a): where W is C, G, or C - G '(in which G is optionally esterified carboxyl, and G' is halogen); X is oxygen.Optionally oxidized sulphur or - (CH2) Q (where q is 0 to 5); R is an optionally substituted amino group or Hetrocyclic ring; the ring B is a of 5 to 7 members containing nitrogen and optionally SuBstituu00eddo; L is hydrogen, an optionally substituted hydrocarbon residue, optionally substituted acyl, optionally substituted carbamou00edla, tiocarbamou00edla optionally replaced,Provided that, where W is C, G, l is hydrogen, acyl, optionally substituted, carbamou00edla optionally replaced, alcoxicarbonila optionally replaced,Tiocarbamou00edla optionally replaced or sulfonila optionally substituted; n is 0 or 1; the ring may have a substituent.It is also described a process for the production of the compound (a) and a pharmaceutical composition containing the compound (a).The pharmaceutical composition is useful for an anti-inflammatory drug, particularly a drug for prevention or treatment of arthritis, a drug to inhibit bone ressoru00e7u00e3o,An immunosuppressant or analogue.