'Isolated infectious recombinant respiratory syncytial virus, particulate, processes to stimulate an individual's immune system to induce protection against respiratory syncytial virus and to produce a particle of recombinant respiratory syncytial virus, vaccine to induce protection against recombinant respiratory syncytial virus. composition and collection of recombinant respiratory syncytial virus '

摘要

'' Respiratory Syncytial Virus Recombinant INFECTIOUS ISOLATED EVEN particle, PROCESSES TO ENCOURAGE THE SYSTEM IMMUNE an individual to INDUCE PROTECTION AGAINST Respiratory Syncytial Virus AND PRODUCE A virus particle respiratory syncytial RECOMBINANT, VACCINE TO INDUCE PROTECTION AGAINST Respiratory Syncytial Virus RECOMBINANT, COMPOSITION AND RECOMBINANT RESPIRATORY SYNCHIC VIRUS. '' Attenuated respiratory syncytial virus (RSV) and its vaccine compositions are produced by introducing specific mutations associated with attenuating phenotypes in the wild type or RSV that is attenuated incompletely by cold passage or by introducing mutations that produce viruses with a phenotype sensitive to temperature (MV ts MU) or adapted to the cold (MU ca MV). Alternatively, recombinant RSV and its vaccine compositions incorporate attenuating mutations and other mutations that specify desired structural or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporates desired mutations specified by inserting, deleting, replacing or rearranging a selected nucleotide nucleotide sequence, gene or gene segment in an infectious RSV clone. An individual's immune system is stimulated to induce protection against infection by natural RSV or, in a multipurpose way, against infection by RSV and another pathogen, such as PIV, through administration of attenuated, biologically derived or recombinant RSV.