Compounds, use and process for their preparation, pharmaceutical composition, and, process for treating depression, anxiety, parkinson's disease, obesity, cognitive disorders, sudden illnesses, neurological and neuroprotective disorders to protect against conditions such as stroke in human beings.

摘要

"COMPOUNDS, USE AND PROCESS FOR THE PREPARATION OF THE SAME, PHARMACEUTICAL COMPOSITION, AND, PROCESS FOR THE TREATMENT OF DEPRESSION, ANXIETY, PARKINSON'S DISEASE, OBESITY, COGNITIVE DISORDERS, SUDDENNESS TREATMENTS, NON-CONTROLLING DRUGS IN HUMAN BEINGS ". Compounds of formula (I) are described: including their pharmaceutically acceptable salts in the form of individual enantiomers, racemates, or other mixtures of enantiomers, where Ar is phenyl, naphthyl or benzo [b] thiophenyl, each of which can be optionally substituted ; R ~ 1 ~ and R ~ 2 ~, which can be the same or different, independently are a) H, b) an alkyl group containing from 1 to 6 carbon atoms, c) an alkenyl group containing from 3 to 6 carbon atoms carbon, d) a cycloalkyl group containing 3 to 7 carbon atoms, e) a cycloalkylmethyl group in which the ring contains 3 to 7 carbon atoms, f) an optionally substituted aryl or heteroaryl group, g) an arylalkyl group or heteroarylalkyl each optionally substituted; or R ~ 1 ~ and R ~ 2 ~ form an alkylene chain optionally substituted by one or more alkyl groups each containing 1 to 3 carbon atoms, such that, together with the atoms to which they are attached, they form a 5- or 6-membered ring; R ~ 3 ~ is a) H, b) an aryl or heteroaryl group each optionally substituted, c) an optionally substituted arylmethyl group; or d) an alkoxyalkyl group containing 3 to 6 carbon atoms; and R ~ 4 ~ and R ~ 5 ~, which can be the same or different, independently are an alkyl group containing from 1 to 3 carbon atoms, or R ~ 4 ~ and R ~ 5 ~ together with the atom to which they they are linked to form a cycloalkyl ring containing 3 to 6 carbon atoms; processes for preparing such compounds; compositions containing such compounds and their use in the treatment of depression, anxiety, Parkinson's disease, obesity, cognitive disorders, sudden illnesses, neurological disorders and as neuroprotective agents.