Method for Preparation of cells with more than 50 active substance solubility greater than 0.5 g / ml, garnulacion EB aqueous Phase, extrusionEsferonizado SECAD and a mixture comprising the active suatacia and maximum 50 microcrystalline Cellulose hiroxipropilcelulosa BDE Relationship: 4 to 6: 4: 6

摘要

Procedure preparation of cells containing 50% by weight of a Pharmaceutical substance hidrosulibilidad - 0,5 g / ml for granulation phase of the mixture containing the active substance, extrusion, rounded and drying The Wet granulation.Using a mixture of active substance that is composed of: a) at least 50% by weight of at least one active substance with water solubility - 0,5 g / ml (b) a maximum of 50% by weight of a combination of: a) a microcrystalline Cellulose with an average Grain size D 15 - 25 um,And (b) a low substitution hydroxypropyl Cellulose with an average particle size of 10 to 25 um. The Weight ratio of (a): (b) 4: 4 to 6: 4.