Use of minimum dose effective drug forms with beta blockers

摘要

Minimal-dose beta-blocker preparations are used for the short-term therapy of transient functional cardiovascular symptoms and produce in the body only those concentrations of active ingredient which do not produce any significant changes in the physiological values in the cardiovascular system under resting conditions for the specific beta-blocker used in each case and significantly reduce adrenergically induced transient stimulation effects, these being oral, transdermal or topical preparations. This makes differential therapy of functional symptoms possible, which does not apply to conventional beta-blocker preparations designed for long-term therapies. This results in an improvement both in the quality of life and in the benefits/risk ratio of the beta-blockers. The duration of therapy also need not be extended beyond the extent necessary for the symptoms because there is no risk of rebound after discontinuation. Thus, another and novel indication made possible is short-term use for primary therapy of sleep disturbances associated with autonomic syndromes, especially also associated with postmenopausal symptoms.