Use of Thiazolidinedione derivatives for the Treatment or prevention of Falls

摘要

Refers to the use of Thiazolidinedione Derivatives of formula (i) (a), where R1 and R2 are H or alkyl of C1 - C5; R3 and R6 are h, C1 - C6 aliphatic acyl acyl, Acyclic or Aromatic heterocycle; R4 and R5 are h,C1 - C5 alkyl, alkoxy C1 - C5, or together form alquilendioxi c1-c4; n is 1 to 3; W is CH2, co, and chor6; and Z is o or NH; b) of formula (ii), where: R11 is phenyl alkoxy alkyl, cycloalkyl,,,Acyl Aromatic heterocycle, a 5 - 6 members with 1 - 2 n, o or s, nr13r14; R13 and R14 are alkyl or with N, o or s form a Ring of 5-6 members; R12 is a link or alquileno; L1 and L2 are h,Alkyl or together form alquileno; c) of formula (iii), where: R15 and R16 are C1 - C6 h, alkyl, alkoxy C1 - C6, among others; n is 0 - 4.Preferred compounds are (+) - 5 - [[4 - [(3,4 dihydro - 4 - hydroxy - 2,5,7,8 - Tetramethyl - 2H - benzopiran - 2 - il) methoxy] phenyl] methyl] - 2,4 - (Thiazolidinedione troglitazone); 5 - (4 - [2 - (n-methyl-n - (2-pyridyl) amino) ethoxy] benzyl) - 2 - (Thiazolidinedione rosiglitazone); 5 - [1 - [P - metilciclohexil) methoxy] benzyl] - 2,4 - (Thiazolidinedione ciglitazone) 5 - [2 - [P - (5-ethyl-2-pyridyl) ethoxy] benzyl] - 2.4 - Thiazolidinedione (Pioglitazone); 4 - (2 - naftilmetil 1,2,3,4,5) - - - - oxatiadiazol oxide 2, among others.The compounds are useful for treating or Preventing Cataracts