Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkysilylated derivatives and alkaline iodides, and pharmacological activities thereof.

摘要

Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof which are stable and are of a fluid pharmaceutical quality, are obtained by iodohydrination involving, in an organic medium, alkylsilylated derivatives of the trimethylsilyl chloride or trimethylchlorosilane type reacting with an alkaline iodide of the sodium iodide type, followed by the in-situ formation of hydroiodic acid by action of water, hydroiodic acid reacting, for example, with fatty acid esters and, in particular, with the fatty acid methyl esters of rapeseed oil recommended as biological fuel for petrol engines, yielding a product with advantageous low cost price and used in therapy, in particular in treatment of iodo-deprived goitre.