Interleukin 6 mutant improved biological activity relative to wild interleukin 6.

摘要

Interleukin 6 mutant, characterized in that it has at position 176, arginine amino acid INSTEAD OF Serine Amino Acid AS IN interleukin 6 WILDLIFE, AND THE FACT THAT SHOWS LARGEST BIOLOGICAL ACTIVITY THAT interleukin 6 SILVESTRE. FIGURE REPRESENTS THE FIELD GENETICO PBKS plasmid IL-6 BE 176ARG CONTAINING SEQUENCE ENCODING FOR nucleotide mutant interleukin 6 according to the invention, NO glycosylated. This plasmid has been filed in E. COLI K12 BY THE NATIONAL COLLECTION OF INDUSTRIAL BACTERIA AND MARINE LTD. UNDER THE ACCESS NUMBER NCIMB 40526 02/11/1992.