POLYPEPTIDES HAVING A .BETA.-ADREMERGIC RECEPTOR ACTIVITY IN HUMANS, INVOLVED_IN THE LIPOLYTIC RESPONSE, NUCLEIC ACIDS CODING FOR THESE POLYPEPTIDES AND USE OF THESE POLYPEPTIDES FOR THE SCREENING OF ACTIVE SUBSTANCES ON THESE POLYPEPTIDES

摘要

The subject of the invention is new polypeptides having .beta.-adrenergic .alpha receptor activity. ~ Ant: the sequence of 402 amino acids, or a fragment of this sequence, this fragment being such that in particular either it nevertheless contains the sites contained in this sequence and the presence of which is necessary so that, when this fragment is exposed to on the surface of a cell, it is capable of participating in the activation of adenylate cyclase in the presence of an agonist, or it is capable of being recognized by antibodies which also recognize the above-mentioned sequence of 402 amino acids, but do not recognize either the .beta.1 adrenergic receptor or the .beta.2 adrenergic receptor. These polypeptides are useful for the screening of drugs, active on said polypeptides and intended for the treatment of obesity, fatty diabetes, as well as hyperlipidemias.