SUBSTANCE CONTAINING SHIITAKE MUSHROOM HYPHA EXTRACT FOR SCREENING LAK ACTIVITY AND METHOD FOR SCREENING LAK ACTIVITY BY USING THE SAME

摘要

An inexpensively available substance for screening an immunotherapeutic agent having antitumor and/or anticancer activities. A screening method for determining in vitro a substance having a LAK activity potentiating effect suitable for a subject which involves the following steps: (a) collecting the peripheral blood of the subject and preparing a lymphocyte fraction therefrom; (b) preparing a LAK-induction sample by adding the above screening substance to the lymphocyte fraction and a control sample containing no screening substance; and (c) measuring the LAK activities of the induction sample and the control sample and comparing the activities to thereby determine the LAK activity potentiating effect of the screening substance in vitro on the subject.