QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES, MIXTURE OF THEIR ISOMERS OR INDIVIDUAL ISOMERS IN THE FORM OF HYDRATES AND SALTS SHOWING ANTIBACTERIAL ACTIVITY, ISOINDOLE DERIVATIVES AS INTERMEDIATES FOR PREPARATION OF SAID QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES

摘要

FIELD: organic synthesis. SUBSTANCE: invention provides quinolone- and naphthiridonecarboxylic acid derivatives of general formula T-Q, wherein Q is residue of general formula (a), in which R¹ is C_1-4-alkyl optionally substituted by 1-2 halogen atoms, cyclopropyl, or dihalogen substituted phenyl; R² hydroxyl, C_1-3-alkoxy; X¹ halogen; X² hydrogen, halogen, methyl, methoxy, amino, or vinyl; A nitrogen or CR³ group; R³ hydrogen, halogen, methyl, methoxy, vinyl, difluoromethoxy, or, together with R¹ residue, -^*O-CH₂-CH-CH₃ bridge, in which labeled oxygen atom is bound to A group carbon atom; and T is residue of general formula (b), wherein B is amino group and R₄ hydrogen; isomer mixture or individual isomers in the form of hydrate or salt. Compounds T-Q show antibacterial activity. EFFECT: extended choice of antibacterial drugs. 4 cl, 2 tbl, 31 ex