where R1 and R2 are hydrogen atoms or R1 is hydrogen atom and R2 is hydroxyl group or OR1 and R2 in common form cyclic carbonate group of the formula: ; R3 can be - or -oriented and means hydrogen atom or alkylsilyl-group but triethylsilyl is preferable; R4 is hydrogen atom or residue or isoserine residue of the formula (A) where is direct or branched alkyl-group containing one-five carbon atoms; is direct or branched alkyl group containing one-five carbon atoms or tert.-butoxyl-group at condition that when R2 is H then R4 is distinct from H and isoserine residue of the formula (A). Compounds show anticarcinogenic effect with respect to different human tumor forms. Invention describes also method of their synthesis, intermediate compounds and pharmaceutical composition based on the above indicated compounds. Pharmaceutical composition can be administrated by injection or oral route. EFFECT: higher antitumor properties. 8 cl, 2 tbl"/>
DERIVATIVES OF 10-DEACETYLBACCATIN-III AND 10-DEACETYL-14- HYDROXYBACCATIN-III, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION
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DERIVATIVES OF 10-DEACETYLBACCATIN-III AND 10-DEACETYL-14- HYDROXYBACCATIN-III, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION
DERIVATIVES OF 10-DEACETYLBACCATIN-III AND 10-DEACETYL-14- HYDROXYBACCATIN-III, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel compounds of the formula (I) where R1 and R2 are hydrogen atoms or R1 is hydrogen atom and R2 is hydroxyl group or OR1 and R2 in common form cyclic carbonate group of the formula: ; R3 can be - or -oriented and means hydrogen atom or alkylsilyl-group but triethylsilyl is preferable; R4 is hydrogen atom or residue or isoserine residue of the formula (A) where is direct or branched alkyl-group containing one-five carbon atoms; is direct or branched alkyl group containing one-five carbon atoms or tert.-butoxyl-group at condition that when R2 is H then R4 is distinct from H and isoserine residue of the formula (A). Compounds show anticarcinogenic effect with respect to different human tumor forms. Invention describes also method of their synthesis, intermediate compounds and pharmaceutical composition based on the above indicated compounds. Pharmaceutical composition can be administrated by injection or oral route. EFFECT: higher antitumor properties. 8 cl, 2 tbl
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