DERMATAN SULFATE OR ITS SALT, ANTITHROMBOTIC AGENTS, METHOD OF PROPHYLAXIS AND TREATMENT OF THROMBOSIS, METHOD OF PROPHYLAXIS OR TREATMENT OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME, METHOD OF MYOCARDIUM INFARCTION TREATMENT

摘要

FIELD: medicine. SUBSTANCE: invention describes dermatan sulfate or its salt with intrinsic viscosity value 0.8 (100 ml/g) or above using 0.2 M sodium chloride solution as solvent at 30 0.1 C. Indicated dermatan sulfate has 0.15% or less of heparin or heparan sulfate determined by method involving treatment with enzymes that cleave heparin or heparan sulfate and high pressure liquid chromatography. Dermatan sulfate has also 0.07% or less of heparin or heparan sulfate determined by inhibitory effect of active factor in the presence of antithrombin-III using heparin isolated from cow guts as standard substance or 0.05% of less of heparin or heparan sulfate determined by inhibitory effect of active factor-II in the presence of antithrombin-III using heparin isolated from cow guts as standard substance. Dermatan sulfates or their salts are antithrombotic agents that inhibit thrombus distribution and stimulate their lysis. Invention describes also antithrombosis agents, method of prophylaxis or treatment of patients with disseminated intravascular coagulation syndrome and method of treatment of patients with myocardium infarction. EFFECT: improved method of prophylaxis and treatment, valuable medicinal properties. 18 cl, 8 tbl, 6 dwg, 9 ex