Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under- carboxylated osteocalcin

摘要

A method for the assessment of bone fragility and osteoporosis fracture risk characterized by:PPmeasuring in vitro the concentration of under-carboxylated osteocalcin in a biological fluid sample such as serum, plasma or urine;PPcomparing the concentration of under-carboxylated osteocalcin in the test sample with the concentration in a control sample containing levels of under- carboxylated osteocalcin representative of the upper limit of the normal range, concentrations above this upper limit being indicative of increased risk of bone fracture.