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Tetrasulphamoyl- phthalocyanine amp; naphthalocyanine dye derivatives for use in tissue demarcation, imaging, amp; diagnosis of tumour cells amp; diseased lymph nodes
Tetrasulphamoyl- phthalocyanine amp; naphthalocyanine dye derivatives for use in tissue demarcation, imaging, amp; diagnosis of tumour cells amp; diseased lymph nodes
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机译:四硫代甲酰基酞菁和萘酞菁染料衍生物,用于组织标定,肿瘤细胞和患病淋巴结的成像和诊断
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Compounds of formula (I) EMI ID=1.1 HE=60 WI=103 LX=806 LY=75 TI=CF PCand of formula (II) EMI ID=1.2 HE=63 WI=108 LX=806 LY=894 TI=CF PC[whereinBR M is a metal or metalloid;BR each EMI ID=1.3 HE=13 WI=13 LX=901 LY=1656 TI=CF PCis independently an optionally substituted aromatic benzene or naphthalene nucleus;BR each RSP1/SP independently represents hydrogen, CSB1/SB-CSB12/SB alkyl, aryl, substituted aryl or CSB4/SB-CSB6/SB cycloalkyl;BR each RSP2/SP independently represents CSB1/SB-CSB12/SB alkyl, aryl, substituted aryl, CSB4/SB-CSB6/SB cycloalkyl or -(CHSB2/SB)SB2/SBNRSP3/SPSB2/SB (where RSP3/SP = CSB1/SB-CSB12/SB alkyl, aryl or substituted aryl, or RSP3/SPSB2/SB = -[CHSB2/SB]SBp/SB-, where p = 4-6);BR n = 2, 3 or 4;BR RSP4/SP represents a divalent, trivalent or tetravalent group being an aromatic group, a CSB2/SB-CSB10/SB aliphatic group, or a linear or branched polyalkyleneoxy group; and wherein compounds of formula (II) may also be attached to a surfactant molecule] are contrast and imaging agents. These lipophilic dyes can be used to differentiate between tissue groups, in the imaging and diagnosis of diseased lymph nodes) and in treatments involving the removal (by surgery) or in situ destruction of such matter (eg by photodynamic therapy, radiotherapy or sonodynamic therapy).
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