Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents

摘要

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;PP R. sub.1, R.sub. 5 and R.sub.6 are independently a C.sub.1 -C.sub.6 alkyl group;PPR. sub.2, R.sub.3 and R.sub.4 are independently hydrogen or a C.sub.1 -C. sub.6 alkyl group;PPZ is thio, oxy or a methylene group;PPA is a C.sub.1 -C.sub.4 alkylene group;PPX is thio or oxy; andPPG. sub.1 and G.sub.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or - - C(O)- -(CH.sub.2).sub.n --CH.sub.3 and n is an integer 0, 1, 2 or 3; PPor a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti- oxidant chemical additives useful for preventing oxidative deterioration in organic materials.