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Transgenic mammal having a human Ig locus comprising multiple VVH and V 下 K regions, and antibodies produced therefrom
Transgenic mammal having a human Ig locus comprising multiple VVH and V 下 K regions, and antibodies produced therefrom
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机译:具有包含多个VVH和V下K区的人Ig基因座的转基因哺乳动物,以及由此产生的抗体
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摘要
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and V kappa) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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