NEW CALIX CROWN DERIVATIVE, METHOD FOR PRODUCING THE DERIVATIVE, SELF-ASSEMBLY MONOMOLECULAR LAYER AND METHOD FOR IMMOBILIZING PROTEIN MONOMOLECULAR LAYER USING THE SELF-ASSEMBLY MONOMOLECULAR LAYER

摘要

PROBLEM TO BE SOLVED: To solve problems such as concentration, activity, orientation, etc., which conventional protein immobilization method has. ;SOLUTION: This calix crown derivative useful for immobilizing a protein monomolecular layer and essential for producing a self-assembly monomolecular layer is represented by chemical formula (1), chemical formula (2) or chemical formula (3). This method for synthesizing the derivatives is provided. This self-assembly monomolecular layer is produced by immersing a gold substrate or a related metal substrate metallized in vacuum in an organic solvent. This method for immobilizing the carbonate monomolecular layer comprises immobilizing a protein having ≥20,000 D (20KD) molecular weight to the self-assembly monomolecular layer.;COPYRIGHT: (C)2001,JPO