Bird paramyxovirus cdna, rna, process for generating infectious copy of bird paramyxovirus and for distinguishing unvaccinated animals or animals vaccinated with an ndv vaccine, infectious copy of bird paramyxovirus, vaccine, and, diagnostic set.

摘要

"AVE PARAMYXOVIRUS cDNA, RNA, PROCESS TO GENERATE INFECTIOUS COPY OF AVE PARAMYXOVIRUS AND TO DISTINGUISH NON-VACCINATED ANIMALS OR ANIMALS VACCINATED WITH AN NDV VACCINE, INFECTIOUS COPY OF PARAMYXOVIA, CONAMOXO, VACCINIA, AGAINSTEIN,. The invention relates to the process for generating Newcastle disease infectious virus (NDV) entirely from the cloned full-length cDNA and the use of vaccines and diagnostic assays generated and derived from said process. The process offers the possibility to modify the NDV genome through genetic modification and allows the introduction of mutations, deletions and / or insertions. The process can be used to modify the virulence of NDV, thereby generating new live attenuated vaccines with enhanced properties. The process can be used to modify the antigenic elaboration of NDV thus allowing the generation of live NDV marker vaccines that can be serologically distinguished from field NDV strains.