Compound, and, processes to treat hypertension, inflammation, allergic reactions, mast cell degranulation, tumors and cardiac hypoxia and to protect against cerebral ischemia, to determine the presence of tumor cells that have a high concentration of receptors of adenosine a3 in a patient and in a cell sample, and to determine the presence of residual tumor cells following surgical removal of a tumor

摘要

"COMPOSITE, AND, PROCESSES TO TREAT HYPERTENSION, INFLAMMATION, ALLERGIC REACTIONS, MASTOCYTE DEGRANULATION, TUMORS AND HEART HYPOXY AND PROTECT AGAINST CEREBRAL ISCHEMIA TO DETERMINE CONTEMPORARY CONTENT. OF ADENOSINE A ~ 3 ~ IN A PATIENT AND A CELL SAMPLE, AND TO DETERMINE THE PRESENCE OF RESIDUAL TUMOR CELLS FOLLOWING SURGICAL REMOVAL OF A TUMOR ". The compounds of the formulas described here in which R, R ^ 1 ^, R ^ 2 ^, R ^ 3 ^ and A have the meanings given in the specification, are endowed with selective A ~ 3 ~ adenosine receptor agonist activity. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A ~ 3 ~ receptor or can be used in a diagnostic application to determine the relative binding of other compounds to the A ~ 3 ~ receptor. The compounds can be labeled, for example with fluorescent labels or radio labels and labels used in vivo or in vitro to determine the presence of tumor cells that have a high concentration of A ~ 3 ~ adenosine receptors.