ISOBENZOFURANS, A PHARMACEUTICAL COMPOSITION AND AISOBENZOFURANS, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR THE TREATMENT OF DISORDER OR DISEASE S METHOD FOR THE TREATMENT OF DISORDER OR DISEASE SENSIBLE TO THE ACTION OF 5-HT1A ENSIBLE TO THE ACTION OF 5-HT1A

摘要

(I) (1) (2) (3) (4) The present invention relates to benzofuran derivatives having general Formula (I). A is selected from (1), (2), (3), (4) wherein: Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl-Aryl, or C1-6-alkyl-O-Aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkylene and C2-6-alkynylene; its enandomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.