Water dispersed ivermectin dosage form used for curing ecto- and endoparasitic diseases

摘要

The invention relates to veterinary medicine and general medicine and can be used for curing ecto- and endoparasitic diseases. The inventive water dispersed ivermectin or avermectin dosage form contains water as a solvent, dimethyl acetamide or propilene glycol or glyceroformal as a co-solvent, detergents like tween 80, solutol, cremophore and other polyoxyethylated derivatives of natural oils used as a micella forming agent, benzyl alcohol, parabenes as preservatives, a phosphato-citrated buffer solution and additionally a vitamin E (tocopherols). The curing effect of the inventive dosage band in comparison with the analogue, applied during various ecto- and endoparasitic diseases of cattle is higher than 41.1-50.5 % and 36.6-43.3 % for sheep. The maximum curing effect is obtained in a singe puncture of a dose per 50 kg body weight. The drug product in therapeutic doses is non-toxic.