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A method to map and isolate regions of chromosomes that interact or associate functionally within or between chromosomes in vivo
A method to map and isolate regions of chromosomes that interact or associate functionally within or between chromosomes in vivo
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机译:绘制和分离染色体区域的方法,该区域在体内染色体之间或内部具有功能性相互作用或缔合
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摘要
The present invention relates to a linear DNA vector and to a method for identifying chromosomal regions having a physical proximity within a living cell, and/or for locating in chromosomes of a living cell a DNA double strand break having a physical proximity with a known non-repetitive DNA sequence. The linear DNA vector has a first end which comprises a nucleotide sequence capable of homologous recombination to a first region of a cell chromosome which comprises a known non-repetitive DNA sequence. The linear DNA vector also has a second end which comprises a nucleotide sequence non-homologous to the chromosomes of the cell and being capable of illegitimate integration with a second region of a chromosome in physical proximity to the first chromosomal region.
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