Assaying of mitochondrial intermembrane space protein translocation

摘要

Compositions and methods are provided for identifying agents that alter mitochondrial intermembrane space protein (MISP) translocation. The screening methods generally detect agents that alter the level of detectable extramitochondrial MISP following exposure of a cell to an agent known or suspected to induce mitochondrial intermembrane space protein translocation. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.