首页>
外国专利>
Determination of log P coefficients via A RP-HPLC column
Determination of log P coefficients via A RP-HPLC column
展开▼
机译:通过RP-HPLC色谱柱测定log P系数
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention provides a RP-HPLC method, for the determination of logPoct values, which combines ease of operation and high accuracy, and which has been shown to work for a set of 36 molecules largely comprised of drugs. The general features of the method are: i) compound sparing (≤1 mL of a 30-50 µg/mL solution needed), ii) rapid determinations (20 minutes on average), iii) low sensitivity to impurities, iv) wide lipophilicity range (6 logPoct units), v) good accuracy, vi) excellent reproducibility. A linear free energy relationship (LFER) analysis, based on solvation parameters, shows that the method encodes the same information obtained from a shake-flask logPoct determination. The value generated via this method is referred to as ElogPoct.
展开▼