1--18--4- 1-Aryl-18-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor

摘要

The present invention relates to a type Ⅳ phosphodiesterase inhibitor containing the 1-aryl-1,8-naphthyridin-4-one derivative or a salt or solvate thereof, and this active ingredient of the formula Ⅰ.; Formula Ⅰ; Wherein; R ¹ is a substituted or unsubstituted aryl group or a substituted or unsubstituted represents unsubstituted heteroaryl group,; R ^2, R ³ and R ⁴ are independently a hydrogen atom, a substituted or represents an unsubstituted lower alkyl group or a halogen atom,; X is a group NR ⁵ R ⁶ or a group OR ⁷ (wherein, R ⁵ and R ⁶ independently represent a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group ring or it represents a substituted or unsubstituted heteroaryl group, R ⁷ represents a hydrogen atom, substituted, or unsubstituted lower alkyl group or a substituted ring, or represents a cycloalkyl group is unsubstituted).