Provided is a method of substantially reducing the daily dosage range required to eliminate pain in nearly 90% of patients by administering an oral solid phase inhibitory formulation comprising 10 to 40 mg of oxycodone or a salt thereof to the patient. do.;Oxycodone mean maximum blood concentration of 6 to 60 mg / ml up to 2 to 4.5 hours after administration of the formulation and 10 to 14 hours after repeated dosing with “q12h” (ie every 12 hours) through steady state conditions Giving an average minimum blood concentration of 3 to 30 mg / ml. In another form, there is provided a method of administering an oral solid release inhibitory formulation comprising up to 160 mg of oxycodone or a salt thereof to substantially reduce the daily dosage range required to eliminate pain in nearly all patients, This resulted in 120mg / up to 10-14 hours after dosing repeatedly with “q12h” (ie every 12 hours) through an average maximum blood concentration of oxycodone up to 240 mg / ml and steady-state conditions at an average of 2 to 4.5 hours after administration. Mean minimum blood concentrations up to ml are achieved. There is also provided a release inhibitory oxycodone formulation to achieve the above.
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