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Agents for the therapy of human diseases, in particular for the therapy of tumors such as colon carcinomas and melanomas or for tissue regeneration and promotion of hair growth
Agents for the therapy of human diseases, in particular for the therapy of tumors such as colon carcinomas and melanomas or for tissue regeneration and promotion of hair growth
The invention relates to agents for treating human diseases which are based on substances that specifically influence the binding of beta -catenin on LEF-1/TCF- transcription factors, APC or conductin/axin. The invention particularly relates to the identification and use of hydrophobic pockets on the molecular surface in the proximity of the essential binding points for the binding partners of ss-catenin with the aim of optimizing these substances. The invention also relates to the use of the substances, preferably for treating tumors such as colonic cancers and melanomas or for regenerating tissue and promoting hair growth.
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