Antiatherosclerotic medicament containing chromocarb (preferably as salt) and cyaninosides (preferably as flavylium salts), effective by retarding oxidative lipid metabolism and/or scavenging free radicals

摘要

Antiatherosclerotic medicament contains at least one chromone compound (I), selected from chromocarb (Ia) (preferably in the form of a chromone-2-carboxylic acid carboxylate salt) and cyaninosides (Ib) (preferably in the form of flavylium salts), for retarding oxidative metabolism of lipids circulating in the blood and/or scavenging anionic free radicals. An independent claim is also included for the use of (I) for the production of a medicament as above. ACTIVITY : Antiarteriosclerotic. In tests in genetically atherosclerotic mice, oral administration of chromocarb diethylamine salt (I'a) at 1.8 mg (or 40 mg/kg) per day for 3 days reduced the peroxidized lipid level by 54% and the surface area of aortic atherosclerotic lesions from 27917 Microm2 to 12500 Microm2 (both relative to untreated controls). MECHANISM OF ACTION : Oxidative lipid metabolism retardant; anionic free radical scavenger; synergist.