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Human serum albumin expression and use in gene therapy
Human serum albumin expression and use in gene therapy
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机译:人血清白蛋白的表达及其在基因治疗中的应用
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摘要
The present invention relates to DNA vectors as a means of gene therapy for the use in treatment of human and animal disease states that are characterised by failure or inadequate functioning of the liver. This results in the lowering of the blood levels of certain important proteins produced by the liver leading to hypoalbuminaemia, anaemia, thrombocytopenia and coagulation disorders related to liver failure. The invention also relates to an expression cassette for expressing a human serum albumin into a mammalian cell comprising: SL LI(i) a cDNA sequence of the human serum albumin, LI(ii) a transcriptional control sequence operably linked to said cDNA sequence. /SL
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