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Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment
Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment
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机译:包含丙型肝炎病毒片段的转基因小鼠丙型肝炎病毒模型
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摘要
Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.
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