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Mammaglobin, a breast-specific protein secreted from breast cancer
Mammaglobin, a breast-specific protein secreted from breast cancer
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机译:乳房珠蛋白,一种从乳腺癌中分泌出来的乳房特异性蛋白
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摘要
A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
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