Mareks disease virus genes and their use in vaccines for protection against mareks disease

摘要

A nucleotide sequence encoding the gp82 polypeptide of Mareks disease virus is disclosed. Also disclosed are recombinant viruses which are useful as vaccines for protecting against Mareks Disease, preferably containing two more genes encoding Mareks Disease Virus antigens such as glyprotein B and glycoprotein gp82, under the control of a poxvirus promoter within a region of the DNA of fowlpox virus which is not essential for virus growth. Also provided is a vaccine exhibiting a synergistic immunoprotective effect, comprising a recombinant fowlpox virus expressing Mareks Disease Virus gB protein in combination with turkey herpesvirus. A method of immunizing poultry, comprising administering any of the disclosed vaccines, is also provided.