首页> 外国专利> Crystalline form, pharmaceutical formulation, use of a crystalline form, use of a substance, methods for the treatment or prophylaxis of, conditions associated with reduced insulin sensitivity, and delipidemia, type 2 diabetes mellitus, hyperglycemia, hyperinsulinemia, hypertension and / or abdominal obesity, and, process for the preparation of a crystalline form of a compound of formula i

Crystalline form, pharmaceutical formulation, use of a crystalline form, use of a substance, methods for the treatment or prophylaxis of, conditions associated with reduced insulin sensitivity, and delipidemia, type 2 diabetes mellitus, hyperglycemia, hyperinsulinemia, hypertension and / or abdominal obesity, and, process for the preparation of a crystalline form of a compound of formula i

机译:结晶形式,药物制剂,结晶形式的使用,物质的使用,治疗或预防的方法,与胰岛素敏感性降低和血脂异常有关的疾病,2型糖尿病,高血糖,高胰岛素血症,高血压和/或腹部肥胖以及制备式I化合物的晶型的方法

摘要

"CRYSTALLINE FORM, PHARMACEUTICAL FORMULATION, USE OF A CRYSTALLINE FORM, USE OF A SUBSTANCE, METHODS FOR TREATMENT OR PROPHYLAXIS OF, CONDITIONS ASSOCIATED WITH REDUCED INSULIN SENSITIVITY, AND DELIPIDEMIA, HYPERTEMINUM HYPERTEMINUM, AND / OR ABDOMINAL OBESITY, AND, PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF A COMPOUND OF FORMULA I ". The present invention relates to a new crystalline form of the (S) -2-ethoxy-3- [4- (2- (4-methanesulfonyloxyphenyl) ethoxy) phenyl] propanoic acid compound, shown by formula (1) or a pharmaceutically acceptable salt and solvates thereof. The invention also relates to methods of treating one or more metabolic disease conditions, particularly those associated with Insulin Resistance Syndrome, and the use of a crystalline form of the compound, or a pharmaceutically acceptable salt thereof, or a its solvate, in the manufacture of a medicine for use in one or more of the aforementioned conditions. The invention further relates to pharmaceutical compositions containing a crystalline form of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as an active ingredient, as well as processes for the manufacture of a crystalline form of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
机译:“结晶形式,药物制剂,结晶形式的使用,物质的使用,治疗或预防的方法,与胰岛素敏感性降低有关的情况,以及偏瘫,高,低度,高,//大,大/小病“式I化合物的结晶形式”。本发明涉及式(1)所示的(S)-2-乙氧基-3- [4-(2-(4-甲磺酰氧基苯基)乙氧基)苯基]丙酸化合物的新晶型或药学上可接受的盐及其溶剂化物。本发明还涉及治疗一种或多种代谢疾病,特别是与胰岛素抵抗综合症有关的疾病的方法,以及该化合物的结晶形式或其药学上可接受的盐或其溶剂化物在制备甲氧西林酸中的用途。用于一种或多种上述疾病的药物。本发明进一步涉及含有化合物或其药学上可接受的盐或其溶剂化物的晶体形式作为活性成分的药物组合物,以及化合物的晶体形式或药物的制备方法。其可接受的盐或其溶剂化物。

著录项

  • 公开/公告号BR0016131A

    专利类型

  • 公开/公告日2002-08-20

    原文格式PDF

  • 申请/专利权人

    申请/专利号BR20000016131

  • 发明设计人

    申请日2000-11-29

  • 分类号C07C309/66;A61K31/192;A61P5/48;A61P3/00;

  • 国家 BR

  • 入库时间 2022-08-22 00:46:07

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