Sample formation, methods of preparing a formation of multiple solid forms of a compound of interest, of screening a plurality of solid forms of a compound of interest and conditions and / or components for compatibility with one or more selected solid forms of a compound of interest, to identify optimal solid forms of a compound of interest and to determine sets of conditions and / or components to produce solid forms of a compound of interest, a set of processing parameters and / or components and the conditions and / or components that produce a compound of interest or a diastereomeric derivative and system for identifying optimal solid forms of a compound of interest

摘要

"SAMPLE FORMATION, METHODS OF PREPARING A FORMATION OF MULTIPLE SOLID FORMS OF A COMPOUND OF INTEREST, OF TRIATING A PLURALITY OF SOLID FORMS OF A COMPOUND OF INTEREST AND CONDITIONS AND / OR COMPONENTS FOR COMPATIBILITY WITH ONE OR MORE COMPOSITES WITH ONE OR MORE COMPANIES INTEREST, TO iDENTIFY WAYS sOLID of great A COMPOUND INTEREST AND dETERMINE cONDITIONS SETS AND / OR COMPONENTS TO PRODUCE FORMS OF sOLID AN INTEREST COMPOUND, A PROCESSING pARAMETERS SET AND / OR COMPONENTS AND cONDITIONS AND / OR COMPONENTS THAT PRODUCE A COMPOUND OF INTEREST OR ITS DIASTEREOMERIC DERIVATIVE AND SYSTEM TO IDENTIFY OPTIMAL SOLID FORMS OF A COMPOUND OF INTEREST ". The invention relates to formations of solid forms of substances, such as compounds and methods of rapid screening for them, to identify solid forms, particularly of drugs, with increased properties. Such properties include improved bioavailability, solubility, stability, supply and manufacturing processing characteristics. The invention relates to a practical and cost effective method for quickly screening hundreds to thousands of samples in parallel. The invention further provides methods for determining the conditions and / or ranges of conditions required to produce crystals with the desired compositions, particle sizes, habits or polymorphic shapes. In yet another aspect, the invention provides high production methods for identifying sets of conditions and / or combinations of components compatible with solid joint shapes, for example, conditions and / or components that are compatible with advantageous polymorphs of a particular drug.