Compound, pharmaceutical composition, methods to modulate the activity of a chemokine receptor, to prevent HIV infection, to treat HIV infection, to delay the onset of AIDS, or to treat AIDS and to treat an inflammatory disease, and, combination

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION METHODS FOR MODULATING THE ACTIVITY OF A CHEMOCCIN RECEPTOR, TO PREVENT HIV INFECTION, TREAT HIV INFECTION, DELAY THE START OF AIDS, OR TREAT AIDS AND TO TREAT INFLAMMATORY DISEASE, AND, COM. The present invention consists of an unprecedented series of heterocycles functionalized as chemokine receptor modulators of formula I useful as modulators of chemokine receptor activity. The compounds are useful in the treatment and prevention of the AIDS virus. Also taught are intermediates useful in the preparation of final products, pharmaceutical compositions containing the final products.