Inhibitors of metalloproteases compounds containing Side Chains carbociclicas, Pharmaceutical composition,Useful for treating a disease associated with unwanted metalloprotease activity, such as Arthritis or cancer.

摘要

Disclosed are compounds that are inhibitors of metalopropteasas and which are effective in treating conditions characterized by excess activity of these Enzymes.In particular, the compounds have a structure according to formula (i).Where R1, R2, N, a, e, e, L, L, G, and Z have the meanings described in the specification and Claims, as well as optical isomers,Diastereomers and Enantiomers of formula (i), and pharmaceutically acceptable salts, esters and amides biohidrolizables, these imides.Also described are Pharmaceutical compositions comprising the compoundAnd Methods of treating Diseases related to metalloproteinases using the compounds or the pharmaceutical compositions.