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Process for preparing of lercanidipine hydrochloride and their use for the treatment of angina and coronary disease
Process for preparing of lercanidipine hydrochloride and their use for the treatment of angina and coronary disease
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机译:盐酸乐卡地平的制备方法及其在心绞痛和冠心病治疗中的应用
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摘要
A process for the preparation of methyl 1,1,N-trimethyl-N-(3,3-diphenyl-propyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate (lercanidipine) of formula I comprises reacting an acid halide of 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol in an aprotic solvent. The product can be isolated by industrially applicable crystallization techniques and is obtained in high yield as its anhydrous hydrochloride, a form which possesses high stability and low hygroscopicity.
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