Substituted aminomethyl-chromans are used for the regenerative treatment of neurological conditions which are the sequelae of damage due to surgical intervention, exposure to toxic agents, infections, tumours, and other diseases and conditions

摘要

The substituted aminomethyl-chromans of formula (I) and optical isomers and salts thereof are used for the regenerative treatment of neurological conditions which are the sequelae of damage due to surgical interventions, infections, implantations, exposure to toxic agents, tumours, nutritional deficits, metabolic disorders, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, drug abuse or drug addiction, bone marrow disorders and/or injuries, dystrophy or degeneration of the neural retina or peripheral neuropathies; wherein in the formula (I): R1 is H R2 is H, OH, -OCH3, -OCH2CH3, OCH(CH3)2 or -OCH2C(CH3)2-Cl or R1 and R2 together form a radical of formula (II) R3 represents cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl or o-benzenesulfimidyl n is selected from 1, 2, 3, 4, or 5 The compounds of formula (I) can also be used for the treatment of Alzheimer's disease in combination with surgical implantations and/or prostheses.