Non bicycle amines and phenylacrylonitrile for the treatment of restless legs Symphony

摘要

It refers to a mixture containing (a) isocycloethane I from 0.1 mg to 50 mg / day. In this compound, R1, R2 and R3 are h, C1-C6 tar, alquenilo C3-C5, c13-c5 tar, and R1 and R2 combine to form a possibly heterocyclic C3-C7 amine; X is h, C1-C6 tar, halogen, hydroxy, alcoxyl, cyanide, etc.; a, CH, CH2, Ch halogeno, chch3, C = O, C = s, c-sch3, SO2, etc.; B is CH2, CH, N, NH, O, etc.; n is 0-1; D is ch, CH2, ch halogeno, O, N, etc. If a is oxygen, the compound is (5R) - 5 - (methylamine) - 5,6-dihydro-4h-pyridyl-azole [4,5,1-ij] quinoline-2 (1H) - ona; (b) from 10 mg to 100 mg / day, there is a second-class non substitute phenylpropane, n is 0-3;R1 and R2 are h, oh (if R4 is not h),CH, ch2cn, etc.; R3 es h, CF3, ch2cf3, C1-C8 tar, etc.; R4 es h, CF3, ch2cf3, C1-C8 tar, etc. Composition is an effective way to treat restless leg Symphony