Recombinant cytomegalovirus expression system targeting the immediate-early gene region

摘要

The present invention consists in a recombinant cytomegalovirus comprising: a cytomegalovirus genome including within the immediate-early (IE) gene region of the virus genome, a genetic cassette including at least a promoter adjacent to at least a DNA sequence and a polyadenylation stop sequence, wherein (1) the promoter is adapted to drive the expression of the DNA sequence, and (2) the promoter, DNA sequence and the polyadenylation stop sequence is heterologous to the virus in which the cassette is inserted.