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ARGININE ANALOGUES HAVING NITRIC OXIDE SYNTHASE INHIBITOR ACTIVITY
ARGININE ANALOGUES HAVING NITRIC OXIDE SYNTHASE INHIBITOR ACTIVITY
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机译:具有一氧化氮合酶抑制剂活性的精氨酸类似物
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PCT No. PCT/FR96/00337 Sec. 371 Date Sep. 10, 1997 Sec. 102(e) Date Sep. 10, 1997 PCT Filed Mar. 4, 1996 PCT Pub. No. WO96/27593 PCT Pub. Date Sep. 12, 1996A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and -NO2, E is -O- or a covalent bond, n is an integer from 1 to 12, R1 and R2 are individually alkyl of 1 to 6 carbon atoms or taken together with the nitrogen to which they are attached form an optionally unsaturated 5 to 6-member ring of the formula -NX and X is selected from the group consisting of oxygen, sulfur, methylene and N-R', R' being hydrogen or an alkyl of 1 to 6 carbon atoms, and their pharmaceutically acceptable acid addition salts useful to inhibit -NO synthase.
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