T-CELLS AND MOLECULES INVOLVED IN IMMUNE REGULATION

摘要

Novel cells and molecules involved in immune regulation are disclosed. The novel cells are regulatory T cells having the phenotype CD3+ alpha beta TCR+CD4-CD8-CD44-CD28-NK1.1-. The regulatory cells express high levels of Ly-6A and osteopontin while non-regulatory cells do not. Inhibiting Ly-6A or osteopontin inhibits the suppressive properties of the cells.