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VECTOR CONSTRUCTS FOR GENE-THERAPY MEDIATED RADIONUCLIDE THERAPY OF UNDIFFERENTIATED AND MEDULLARY THYROID CARCINOMAS AND NON-THYROIDAL TUMOURS AND THE METASTASES THEREOF
VECTOR CONSTRUCTS FOR GENE-THERAPY MEDIATED RADIONUCLIDE THERAPY OF UNDIFFERENTIATED AND MEDULLARY THYROID CARCINOMAS AND NON-THYROIDAL TUMOURS AND THE METASTASES THEREOF
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机译:基因治疗介导的未分化和延髓性甲状腺癌和非甲状腺肿瘤及其放射性转移的放射性核素治疗
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摘要
The invention relates to vector constructs, comprising vector DNA which includes regulatory sequences, the NIS gene coding for the sodium/iodide symporter, the TPO gene coding for thyroidal peroxidase and use thereof for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states, whereby treatment occurs before or concurrent with a radionuclide therapy, in particular, with iodine-131, or astatine-211. The invention further relates to use of two or several vector constructs for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states.
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