- Methods of Treating Disorders Related to Protease-activated Receptors-induced Cell activation

摘要

PURPOSE: Provided is a method of treating disorders related to protease-activated receptors(PARs)-induced cell activation, such as thrombin-inducing platelet aggregation, effectively. CONSTITUTION: The method for treating disorders related to protease-activator receptor(PARs)-induced cell activation is characterized by administrating an effective amount of a compound represented by formula(1) into non-human mammals. In the formula(1), Ar1, Ar2 and Ar3 are independently phenyl, thienyl, furyl or pyrrolyl; R1, R2, R3, R4, R5 and R6 are independently H, halogen, -OR, -OH, -SR, -SH, -R, -C(=O)OH, -C(=O)OR, -C(=O)SH, -C(=O)SR, -C(=O)NRR', -ROH, -ROR', -RSR', -RSH, -NRR', -NHR, -NH2, -RNR'R", -RNH2, -RNHR' or -RSR' or, R1 and R2, R3 and R4, R5 and R6 are -ORO- together(wherein R, R' and R" are independently C1-4 alkyl); and n is an integer of 1, 2 or 3.