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Crud Drug of Scilla scilloides having Anti-Cancer Activity
Crud Drug of Scilla scilloides having Anti-Cancer Activity
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机译:具有抗癌活性的绵枝illo药
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摘要
PURPOSE: A crude drug extract of Scilla scilloides and their use as anticancer active substance caused by cytotoxicity generated by inhibition of various enzyme actions, formation inhibition of a cell membrane, DNA replication, DNA transcription or protein synthesis inhibition, etc. are provided. Because the extract is free from toxicity and side effects and exhibits strong activity against a cancer cell, it is useful as an anticancer agent. CONSTITUTION: The crude drug exact is prepared by the following process consisting of: extracting Scilla scilloides in methanol with refluxing; suspending the extract in an excess amount of water and extracting with shaking to give a butanol solubilizing part; dissolving the butanol solubilizing part in methanol and subjecting to chromatography to obtain an active fraction; and freeze drying the active fraction. The chromatography is sephadex LH-20 gel column chromatography or YMC gel column chromatography.
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