DERIVATIVES OF 7-3-4-(6-FLUOROBENZODISOXAZOL-3-YL)-PIPERIDINE-1-YLPROPOXY- CHROMEN-4-ONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF D₂-, 5-HT_2a- AND H₁-RECEPTORS AND METHOD OF INHIBITION OF D₂-, 5-HT_2a- AND H₁-RECEPTORS IN TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA

摘要

FIELD: organic chemistry, pharmacology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 7-[3-[4-(6- fluorobenzo[d]isoxazol-3-yl)piperidine-1-yl]-propoxy]-chromen-4-one of the formula (I) where R means hydrogen atom, CHO, CH₂OR₂ or COOH; R₁ means alkyl with from 1 to 4 carbon atoms under condition that one of substituent R and R₁ is hydrogen atom and their pharmaceutically acceptable salts designated for use in treatment of patients with psychosis and schizophrenia. Invention relates to also a method of synthesis of these compounds, pharmaceutical composition based on thereof and method of inhibition of D_2--, 5-HT_2a- and H₁-receptors in treatment of patients with psychosis and schizophrenia. EFFECT: synthesis of new compounds used in medicine as drugs, valuable medicinal properties. 7 cl, 3 tbl, 12 ex