Method of screening chemical compounds for modulating the interaction of an EVH1 domain or a protein with an EVH1 domain with an EVH1 binding domain or a protein with an EVH1 binding domain, and a method for detecting said interaction

摘要

The invention relates to methods for the identification of chemical compounds which can modulate the interaction between VASP and zyxin. VASP or a VASP derivative and zyxin or a zyxin derivative, which interact with each other, are brought into contact with a chemical compound under investigation. The influence on the interaction can be determined by means of antibodies for VASP or a VASP derivative and/or zyxin or a zyxin derivative, or by means of fluorescent markings on VASP or a VASP derivative and zyxin or a zyxin derivative.